My idea of north to south would be to start in Richmond KY and head on down. THat is a windy ass road from The Ohio River to Frankfort then From Richmond to forever.....Amazing piece of road stretching across several states and cutting through some pretty remote stretches in the hills of a couple of states.
Those guys at Willville Motorcycle Camp on the Blue Ridge were talking about 421 when I was there early summer. They were grizzled vets of the Dragon who were actively seeking other rides, 421, Back of the Dragon, The Snake and a few more were ones I remember them talking about.....
I really got to take more time off.